Lung adenocarcinoma (conditioned on cigarettes per day)
MTAP · rs7859886
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Who was studied 13,292 European ancestry cases, 67,596 European ancestry controls, 595 African ancestry cases, 62,112 African ancestry controls; replicated in 7,042 European ancestry cases, 13,599 European ancestry controls, 844 African ancestry cases, 3,779 African ancestry controls.
The effect
Each copy of the A allele carried 0.86 times the odds of Lung adenocarcinoma (conditioned on cigarettes per day) (95% confidence interval 0.832-0.889); p = 9 × 10−19.
How common The A allele had a frequency of about 84% in the people studied.
Where it sits Chromosome 9, band 9p21.3 — in an intron of MTAP.
What each result means
A/ATwo copies of the version the research linked to Lung adenocarcinoma (conditioned on cigarettes per day). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Lung adenocarcinoma (conditioned on cigarettes per day). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Lung adenocarcinoma (conditioned on cigarettes per day). This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39366959 · open access
Questions about rs7859886
What is rs7859886?
rs7859886 is a single position in the genome, in or near the MTAP gene. Published research associates it with lung adenocarcinoma (conditioned on cigarettes per day). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7859886 linked to?
On MyGeneLog this position is linked to EGFR Mutation-Positive Lung Adenocarcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs7859886 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7859886 come from?
GWAS Catalog, Nature communications 2024, PMID:39366959. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Lung adenocarcinoma (conditioned on cigarettes per day) (rs7859886). MyGeneLog™. https://www.mygenelog.com/variants/rs7859886