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Who was studied 405,540 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0187 lower (95% confidence interval 0.013-0.024); p = 1 × 10−10.
How common The C allele had a frequency of about 95% in the people studied.
Where it sits Chromosome 19, band 19p13.3 — in an intron of DOT1L.
What each result means
C/CTwo copies of the version the research linked to Height (baseline). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Height (baseline). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Height (baseline). This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40374629 · open access
Questions about rs78591932
What is rs78591932?
rs78591932 is a single position in the genome, in or near the DOT1L gene. Published research associates it with height (baseline). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs78591932 linked to?
On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.
Does having rs78591932 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs78591932 come from?
GWAS Catalog, Nature communications 2025, PMID:40374629. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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