Standard
Corneal structure
TJP1 · rs785422
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Corneal structure — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Corneal structure.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Corneal structure compared to the general population.
Source
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus
Lu Y,
Vitart V,
Burdon KP,
Khor CC,
Bykhovskaya Y,
Mirshahi A,
Hewitt AW,
Koehn D,
Hysi PG,
Ramdas WD,
Zeller T,
Vithana EN
and 78 more — show all
Cornes BK,
Tay WT,
Tai ES,
Cheng CY,
Liu J,
Foo JN,
Saw SM,
Thorleifsson G,
Stefansson K,
Dimasi DP,
Mills RA,
Mountain J,
Ang W,
Hoehn R,
Verhoeven VJ,
Grus F,
Wolfs R,
Castagne R,
Lackner KJ,
Springelkamp H,
Yang J,
Jonasson F,
Leung DY,
Chen LJ,
Tham CC,
Rudan I,
Vatavuk Z,
Hayward C,
Gibson J,
Cree AJ,
MacLeod A,
Ennis S,
Polasek O,
Campbell H,
Wilson JF,
Viswanathan AC,
Fleck B,
Li X,
Siscovick D,
Taylor KD,
Rotter JI,
Yazar S,
Ulmer M,
Li J,
Yaspan BL,
Ozel AB,
Richards JE,
Moroi SE,
Haines JL,
Kang JH,
Pasquale LR,
Allingham RR,
Ashley-Koch A,
Mitchell P,
Wang JJ,
Wright AF,
Pennell C,
Spector TD,
Young TL,
Klaver CC,
Martin NG,
Montgomery GW,
Anderson MG,
Aung T,
Willoughby CE,
Wiggs JL,
Pang CP,
Thorsteinsdottir U,
Lotery AJ,
Hammond CJ,
van Duijn CM,
Hauser MA,
Rabinowitz YS,
Pfeiffer N,
Mackey DA,
Craig JE,
Macgregor S,
Wong TY
Nature genetics · 2013 · PMID 23291589
Questions about rs785422
What is rs785422?
rs785422 is a single position in the genome, in or near the TJP1 gene. Published research associates it with corneal structure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs785422 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs785422 come from?
GWAS Catalog, Nat Genet 2013, PMID:23291589. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants