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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 448,010 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.07 higher (95% confidence interval 0.064-0.076); p = 3 × 10−181.
How common The T allele had a frequency of about 85% in the people studied.
Where it sits Chromosome 4, band 4p16.3 — in the 5′ untranslated region of FGFRL1.
What each result means
C/CNo copy of the version the research linked to Estimated bone mineral density. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Estimated bone mineral density. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Estimated bone mineral density. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 42432248 · open access
Questions about rs78520297
What is rs78520297?
rs78520297 is a single position in the genome, in or near the FGFRL1 gene. Published research associates it with estimated bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs78520297 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs78520297 come from?
GWAS Catalog, Nature genetics 2026, PMID:42432248. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Estimated bone mineral density (rs78520297). MyGeneLog™. https://www.mygenelog.com/variants/rs78520297