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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 342,566 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0154 lower (95% confidence interval 0.01-0.021); p = 7 × 10−9.
Where it sits Chromosome 9, band 9p21.2 — between genes, 112.8 kb from LINGO2.
What each result means
C/CTwo copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Body mass index. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
Scientific reports · 2024 · PMID 38538606 · open access
Questions about rs7851811
What is rs7851811?
rs7851811 is a single position in the genome, in or near the near LINGO2 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7851811 linked to?
On MyGeneLog this position is linked to Childhood Body Mass Index, Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.
Does having rs7851811 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7851811 come from?
GWAS Catalog, Scientific reports 2024, PMID:38538606. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Body mass index (rs7851811). MyGeneLog™. https://www.mygenelog.com/variants/rs7851811