Sensitive

Gastric cancer

ABO · rs7849280

Where this position leads

Condition: Non-Cardia Gastric Cancer

rs7849280 Condition: Non-Cardia Gastric Cancer Non-Cardia Gastric Cancer Condition rs7849280 rs7849280 ABO

What the study found

Who was studied 6,171 Japanese ancestry cases, 27,178 Japanese ancestry controls; replicated in 5,336 Japanese ancestry cases, 11,726 Japanese ancestry controls.

The effect The reported allele is G; the catalogue records no effect size ; p = 3 × 10−13.

Where it sits Chromosome 9, band 9q34.2 — in the 3′ untranslated region of ABO.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Gastric cancer — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gastric cancer.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gastric cancer compared to the general population.
Source

Questions about rs7849280

What is rs7849280?

rs7849280 is a single position in the genome, in or near the ABO gene. Published research associates it with gastric cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7849280 linked to?

On MyGeneLog this position is linked to Non-Cardia Gastric Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs7849280 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7849280 come from?

GWAS Catalog, Cancer Sci 2018, PMID:30281874. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gastric cancer (rs7849280). MyGeneLog™. https://www.mygenelog.com/variants/rs7849280

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