Standard

HDL cholesterol levels

LPL · rs7841189

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

What the study found

Who was studied 25,169 East Asian ancestry individuals; replicated in 45,953 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.172 higher (95% confidence interval 0.14-0.2); p = 2 × 10⁻³⁰.

How common The T allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 8, band 8p21.3 — between genes, 20.6 kb from LPL.

What each result means

C/C No copy of the version the research linked to HDL cholesterol levels. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to HDL cholesterol levels. That is a smaller link than two copies.

T/T Two copies of the version the research linked to HDL cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

Spracklen CN, Chen P, Kim YJ, Wang X, Cai H, Li S, Long J, Wu Y, Wang YX, Takeuchi F, Wu JY, Jung KJ

and 103 more — show all

Hu C, Akiyama K, Zhang Y, Moon S, Johnson TA, Li H, Dorajoo R, He M, Cannon ME, Roman TS, Salfati E, Lin KH, Guo X, Sheu WHH, Absher D, Adair LS, Assimes TL, Aung T, Cai Q, Chang LC, Chen CH, Chien LH, Chuang LM, Chuang SC, Du S, Fan Q, Fann CSJ, Feranil AB, Friedlander Y, Gordon-Larsen P, Gu D, Gui L, Guo Z, Heng CK, Hixson J, Hou X, Hsiung CA, Hu Y, Hwang MY, Hwu CM, Isono M, Juang JJ, Khor CC, Kim YK, Koh WP, Kubo M, Lee IT, Lee SJ, Lee WJ, Liang KW, Lim B, Lim SH, Liu J, Nabika T, Pan WH, Peng H, Quertermous T, Sabanayagam C, Sandow K, Shi J, Sun L, Tan PC, Tan SP, Taylor KD, Teo YY, Toh SA, Tsunoda T, van Dam RM, Wang A, Wang F, Wang J, Wei WB, Xiang YB, Yao J, Yuan JM, Zhang R, Zhao W, Chen YI, Rich SS, Rotter JI, Wang TD, Wu T, Lin X, Han BG, Tanaka T, Cho YS, Katsuya T, Jia W, Jee SH, Chen YT, Kato N, Jonas JB, Cheng CY, Shu XO, He J, Zheng W, Zheng W, Wong TY, Huang W, Kim BJ, Tai ES, Mohlke KL, Sim X

Human molecular genetics · 2017 · PMID 28334899

Questions about rs7841189

What is rs7841189?

rs7841189 is a single position in the genome, in or near the LPL gene. Published research associates it with hdl cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7841189 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs7841189 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7841189 come from?

GWAS Catalog, Hum Mol Genet 2017, PMID:28334899. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

HDL cholesterol levels (rs7841189). MyGeneLog™. https://www.mygenelog.com/variants/rs7841189

← See all variants