DOCK8 · rs78389565
Where this position leads
Condition: Uterine Fibroids
What the study found
Who was studied 53,711 European ancestry female cases, 380,441 European ancestry female controls, 14,905 East Asian ancestry female cases, 69,609 East Asian ancestry female controls, 14,905 Central Asian ancestry female cases, 69,609 Central Asian ancestry female controls, 14,905 South Asian ancestry female cases, 69,609 South Asian ancestry female controls, 5,678 African ancestry female cases, 15,760 African ancestry female controls.
The effect Each copy of the A allele shifted the measure 0.18 lower (95% confidence interval 0.14-0.22); p = 2 × 10−20.
Where it sits Chromosome 9, band 9p24.3 — in an intron of DOCK8.
rs78389565 is a single position in the genome, in or near the DOCK8 gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2025, PMID:40050615. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Uterine fibroids (rs78389565). MyGeneLog™. https://www.mygenelog.com/variants/rs78389565