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Central corneal thickness (MTAG)

RNF183 · rs78371876

Where this position leads

Condition: Central Corneal Thickness

rs78371876 Condition: Central Corneal Thickness Central Corneal Thickness Condition rs78371876 rs78371876 RNF183

What the study found

Who was studied 17,803 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 2.12 higher (95% confidence interval 1.54-2.7); p = 9 × 10−13.

How common The T allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 9, band 9q32 — in an intron of RNF183.

What each result means

C/C No copy of the version the research linked to Central corneal thickness (MTAG). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Central corneal thickness (MTAG). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Central corneal thickness (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs78371876

What is rs78371876?

rs78371876 is a single position in the genome, in or near the RNF183 gene. Published research associates it with central corneal thickness (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs78371876 linked to?

On MyGeneLog this position is linked to Central Corneal Thickness. The research behind each link, and its sources, are set out on that condition page.

Does having rs78371876 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs78371876 come from?

GWAS Catalog, JAMA ophthalmology 2022, PMID:35446358. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Central corneal thickness (MTAG) (rs78371876). MyGeneLog™. https://www.mygenelog.com/variants/rs78371876

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