Standard

Diacylglycerol (16:0/16:0) (Model 1)

near MSRA · rs7836428

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−15, with 3 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 6,817 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.169 lower; p = 1 × 10−10.

Where it sits Chromosome 8, band 8p23.1 — between genes, 14.9 kb from MSRA-DT.

How common each version is

AG
Korean KRGDB
A 22.2% · G 77.8%
Korean Korea4K
A 22.5% · G 77.5%
Korean Korea1K
A 24.6% · G 75.4%
Japanese ToMMo
A 17.9% · G 82.1%
Vietnamese
A 14.3% · G 85.7%
World gnomAD
A 10.5% · G 89.5%
World 1000 Genomes
A 10.1% · G 89.9%
World TOPMed
A 10.6% · G 89.4%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Diacylglycerol (16:0/16:0) (Model 1). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Diacylglycerol (16:0/16:0) (Model 1). That is a smaller link than two copies.
G/G No copy of the version the research linked to Diacylglycerol (16:0/16:0) (Model 1). This is the starting point the study compared everyone against.
Source

Questions about rs7836428

What is rs7836428?

rs7836428 is a single position in the genome, in or near the near MSRA gene. Published research associates it with diacylglycerol (16:0/16:0) (model 1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7836428 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7836428 come from?

GWAS Catalog, Nature communications 2026, PMID:42069741. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Diacylglycerol (16:0/16:0) (Model 1) (rs7836428). MyGeneLog™. https://www.mygenelog.com/variants/rs7836428

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