Who was studied 172,275 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.028 lower (95% confidence interval 0.019-0.037); p = 9 × 10−10.
How common The G allele had a frequency of about 19% in the people studied.
Where it sits Chromosome 8, band 8q24.12 — in an intron of TNFRSF11B.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Eosinophil count — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Eosinophil count.
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Eosinophil count compared to the general population.
rs7834745 is a single position in the genome, in or near the TNFRSF11B gene. Published research associates it with eosinophil count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7834745 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs7834745 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7834745 come from?
GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.