Sensitive

Type 1 diabetes

PRF1 · rs78325861

Where this position leads

What the study found

Who was studied 18,942 European ancestry cases, 501,638 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.282 lower (95% confidence interval 0.2-0.36); p = 2 × 10⁻¹¹.

How common The G allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 10, band 10q22.1 — inside PALD1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Type 1 diabetes — no copies of the reported risk allele.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Type 1 diabetes.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Type 1 diabetes compared to the general population.

Source

Interpreting type 1 diabetes risk with genetics and single-cell epigenomics

Chiou J, Geusz RJ, Okino ML, Han JY, Miller M, Melton R, Beebe E, Benaglio P, Huang S, Korgaonkar K, Heller S, Kleger A

and 4 more — show all

Preissl S, Gorkin DU, Sander M, Gaulton KJ

Nature · 2021 · PMID 34012112

Questions about rs78325861

What is rs78325861?

rs78325861 is a single position in the genome, in or near the PRF1 gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs78325861 linked to?

On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs78325861 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs78325861 come from?

GWAS Catalog, Nature 2021, PMID:34012112. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 1 diabetes (rs78325861). MyGeneLog™. https://www.mygenelog.com/variants/rs78325861

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