Standard

HDL cholesterol

near HLA-DRB9 · rs78279385

Where this position leads

Conditions: Cholesterol (LDL, HDL and Total), Colon Polyp

rs78279385 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition Condition: Colon Polyp Colon Polyp Condition rs78279385 rs78279385 near HLA-DRB9

What the study found

Who was studied 74,970 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.038 higher (95% confidence interval 0.028-0.048); p = 1 × 10−14.

How common The A allele had a frequency of about 48% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 10.5 kb from HLA-DRB9.

What each result means

A/A Two copies of the version the research linked to HDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to HDL cholesterol. That is a smaller link than two copies.
G/G No copy of the version the research linked to HDL cholesterol. This is the starting point the study compared everyone against.
Source

Questions about rs78279385

What is rs78279385?

rs78279385 is a single position in the genome, in or near the near HLA-DRB9 gene. Published research associates it with hdl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs78279385 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total), Colon Polyp. The research behind each link, and its sources, are set out on that condition page.

Does having rs78279385 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs78279385 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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HDL cholesterol (rs78279385). MyGeneLog™. https://www.mygenelog.com/variants/rs78279385

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