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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 402,398 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0673 higher (95% confidence interval 0.049-0.085); p = 2 × 10−9.
How common The G allele had a frequency of about 98% in the people studied.
Where it sits Chromosome 18, band 18q21.32 — between genes, 13.8 kb from MC4R.
What each result means
A/ANo copy of the version the research linked to Triglyceride to HDL cholesterol ratio. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Triglyceride to HDL cholesterol ratio. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Triglyceride to HDL cholesterol ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs78274649 is a single position in the genome, in or near the near MC4R gene. Published research associates it with triglyceride to hdl cholesterol ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs78274649 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs78274649 come from?
GWAS Catalog, Nature genetics 2024, PMID:38200128. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Triglyceride to HDL cholesterol ratio (rs78274649). MyGeneLog™. https://www.mygenelog.com/variants/rs78274649