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Neuroticism

near NEGR1 · rs782214

Where this position leads

Condition: Neuroticism

rs782214 Condition: Neuroticism Neuroticism Condition rs782214 rs782214 near NEGR1

What the study found

Who was studied 523,783 European ancestry individuals; replicated in 59,206 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0123 lower (95% confidence interval 0.0086-0.0159); p = 5 × 10−11.

How common The G allele had a frequency of about 20% in the people studied.

Where it sits Chromosome 1, band 1p31.1 — in an intron of LINC02796.

What each result means

A/A No copy of the version the research linked to Neuroticism. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Neuroticism. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs782214

What is rs782214?

rs782214 is a single position in the genome, in or near the near NEGR1 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs782214 linked to?

On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.

Does having rs782214 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs782214 come from?

GWAS Catalog, Nat Genet 2019, PMID:30643256. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neuroticism (rs782214). MyGeneLog™. https://www.mygenelog.com/variants/rs782214

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