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Red cell distribution width

CLIC2 · rs781930992

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 10,184 White ancestry individuals, 44 Asian ancestry individuals, 6,776 Black individuals, 11,978 Central American ancestry, Cuban ancestry, Dominican ancestry, Mexican ancestry, Puerto Rican ancestry, South American ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.79 lower (95% confidence interval 0.55-1.03); p = 1 × 10−11.

Where it sits Chromosome X, band Xq28 — in an intron of CLIC2.

What each result means

C/C Two copies of the version the research linked to Red cell distribution width. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Red cell distribution width. That is a smaller link than two copies.
G/G No copy of the version the research linked to Red cell distribution width. This is the starting point the study compared everyone against.
Source
Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program
Hu Y, Stilp AM, McHugh CP, Rao S, Jain D, Zheng X, Lane J, Méric de Bellefon S, Raffield LM, Chen MH, Yanek LR, Wheeler M
and 67 more — show all
Yao Y, Ren C, Broome J, Moon JY, de Vries PS, Hobbs BD, Sun Q, Surendran P, Brody JA, Blackwell TW, Choquet H, Ryan K, Duggirala R, Heard-Costa N, Wang Z, Chami N, Preuss MH, Min N, Ekunwe L, Lange LA, Cushman M, Faraday N, Curran JE, Almasy L, Kundu K, Smith AV, Gabriel S, Rotter JI, Fornage M, Lloyd-Jones DM, Vasan RS, Smith NL, North KE, Boerwinkle E, Becker LC, Lewis JP, Abecasis GR, Hou L, O'Connell JR, Morrison AC, Beaty TH, Kaplan R, Correa A, Blangero J, Jorgenson E, Psaty BM, Kooperberg C, Walton RT, Kleinstiver BP, Tang H, Loos RJF, Soranzo N, Butterworth AS, Nickerson D, Rich SS, Mitchell BD, Johnson AD, Auer PL, Li Y, Mathias RA, Lettre G, Pankratz N, Laurie CC, Laurie CA, Bauer DE, Conomos MP, Reiner AP
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
American journal of human genetics · 2021 · PMID 33887194

Questions about rs781930992

What is rs781930992?

rs781930992 is a single position in the genome, in or near the CLIC2 gene. Published research associates it with red cell distribution width. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs781930992 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs781930992 come from?

GWAS Catalog, American journal of human genetics 2021, PMID:33887194. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Red cell distribution width (rs781930992). MyGeneLog™. https://www.mygenelog.com/variants/rs781930992

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