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Who was studied 36,445 European ancestry cases, 316,943 European ancestry controls.
The effect
Each copy of the T allele carried 0.11 times the odds of Osteoarthritis (hip) (95% confidence interval 0.053204755-0.207340587); p = 8 × 10−11.
How common The T allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 3, band 3q27.3 — between genes, 35.2 kb from RTP4.
What each result means
C/CNo copy of the version the research linked to Osteoarthritis (hip). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Osteoarthritis (hip). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Osteoarthritis (hip). That is the strongest link of the three results. A link in a study is not a diagnosis.
rs781661531 is a single position in the genome, in or near the near RTP4 gene. Published research associates it with osteoarthritis (hip). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs781661531 linked to?
On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs781661531 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs781661531 come from?
GWAS Catalog, Cell 2021, PMID:34450027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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