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Who was studied 37,846 British ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.914 lower (95% confidence interval 0.6-1.23); p = 2 × 10−8.
How common The T allele had a frequency of about 75% in the people studied.
Where it sits Chromosome 2, band 2q37.3 — in an intron of D2HGDH.
What each result means
C/CNo copy of the version the research linked to Asthma (age of onset). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Asthma (age of onset). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Asthma (age of onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
The Lancet. Respiratory medicine · 2019 · PMID 31036433
Questions about rs78147778
What is rs78147778?
rs78147778 is a single position in the genome, in or near the D2HGDH gene. Published research associates it with asthma (age of onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs78147778 linked to?
On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.
Does having rs78147778 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs78147778 come from?
GWAS Catalog, The Lancet. Respiratory medicine 2019, PMID:31036433. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 110Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Asthma (age of onset) (rs78147778). MyGeneLog™. https://www.mygenelog.com/variants/rs78147778