Sensitive

Type 1 diabetes

FASLG · rs78037977

Where this position leads

Condition: Type 1 Diabetes

rs78037977 Condition: Type 1 Diabetes Type 1 Diabetes Condition rs78037977 rs78037977 FASLG

What the study found

Who was studied 20,065 European ancestry cases, 33,065 European ancestry controls, 1,045 other-admixed ancestry cases, 1,103 other-admixed ancestry controls, 1,043 African ancestry cases, 3,206 African ancestry controls.

The effect Each copy of the G allele carried 0.88 times the odds of Type 1 diabetes; p = 2 × 10−9.

How common The G allele had a frequency of about 12% in the people studied.

Where it sits Chromosome 1, band 1q24.3 — between genes, 1.7 kb from SLC25A38P1.

What each result means

A/A No copy of the version the research linked to Type 1 diabetes. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Type 1 diabetes. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Type 1 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs78037977

What is rs78037977?

rs78037977 is a single position in the genome, in or near the FASLG gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs78037977 linked to?

On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs78037977?

Subjects that appear in the title or abstract of the same papers as this rsID include gut and food intolerance (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs78037977 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs78037977 come from?

GWAS Catalog, Nat Genet 2021, PMID:34127860. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 1 diabetes (rs78037977). MyGeneLog™. https://www.mygenelog.com/variants/rs78037977

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