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Heart failure (MTAG)

ELL · rs78030362

Where this position leads

Condition: Heart Failure

What the study found

Who was studied 762,151 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 6.41 z-score higher; p = 1 × 10⁻¹⁰.

How common The G allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 19, band 19p13.11 — in an intron of ELL.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Heart failure (MTAG) — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Heart failure (MTAG).

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Heart failure (MTAG) compared to the general population.

Source

Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases

Jordà P, Lai Y, Jeuken A, Lemieux Perreault LP, Goulet E, Lahrouchi N, Nozza A, Tanck MW, Guerra P, Cadrin-Tourigny J, de Denus S, Bezzina CR

and 5 more — show all

Lettre G, Busseuil D, Dubé MP, Tardif JC, Tadros R

NPJ genomic medicine · 2025 · PMID 41022758 · open access

Questions about rs78030362

What is rs78030362?

rs78030362 is a single position in the genome, in or near the ELL gene. Published research associates it with heart failure (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs78030362 linked to?

On MyGeneLog this position is linked to Heart Failure. The research behind each link, and its sources, are set out on that condition page.

Does having rs78030362 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs78030362 come from?

GWAS Catalog, NPJ genomic medicine 2025, PMID:41022758. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Heart failure (MTAG) (rs78030362). MyGeneLog™. https://www.mygenelog.com/variants/rs78030362

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