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Pyruvate levels

LDHB · rs78010089

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the T allele shifted the measure 0.06 mmol/L lower (95% confidence interval 0.04-0.08); p = 3 × 10⁻¹⁵.

Where it sits Chromosome 12, band 12p12.1 — in an intron of LDHB.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Pyruvate levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Pyruvate levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Pyruvate levels compared to the general population.

Source

A genetic map of human metabolism across the allele frequency spectrum

Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M, Williamson A, Pietzner M, Langenberg C

Nature genetics · 2025 · PMID 41044249 · open access

Questions about rs78010089

What is rs78010089?

rs78010089 is a single position in the genome, in or near the LDHB gene. Published research associates it with pyruvate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs78010089 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs78010089 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Pyruvate levels (rs78010089). MyGeneLog™. https://www.mygenelog.com/variants/rs78010089

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