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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−10, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 11,327 African American or Afro-Caribbean cases, 105,293 African American or Afro-Caribbean controls, 6,080 Hispanic or Latin American cases, 51,418 Hispanic or Latin American controls, 483 East Asian ancestry cases, 6,188 East Asian ancestry controls, 71,808 European ancestry cases, 357,986 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0501 lower (95% confidence interval 0.036-0.064); p = 4 × 10−11.
How common The A allele had a frequency of about 77% in the people studied.
Where it sits Chromosome 7, band 7p21.1 — in the 3′ untranslated region of HDAC9.
What each result means
A/ATwo copies of the version the research linked to Other chronic ischemic heart disease, unspecified (PheCode 411.8). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Other chronic ischemic heart disease, unspecified (PheCode 411.8). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Other chronic ischemic heart disease, unspecified (PheCode 411.8). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs7798197
What is rs7798197?
rs7798197 is a single position in the genome, in or near the HDAC9 gene. Published research associates it with other chronic ischemic heart disease, unspecified (phecode 411.8). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7798197 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7798197 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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