Sensitive

Alzheimer's disease in APOE e33 or e44 or e43 genotype

USP3 · rs77892656

Where this position leads

What the study found

Who was studied 568,304 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.18 higher (95% confidence interval 0.12-0.24); p = 7 × 10⁻⁹.

How common The G allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 15, band 15q22.31 — in an intron of USP3.

What each result means

A/A No copy of the version the research linked to Alzheimer's disease in APOE e33 or e44 or e43 genotype. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Alzheimer's disease in APOE e33 or e44 or e43 genotype. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Alzheimer's disease in APOE e33 or e44 or e43 genotype. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease

Thomassen JQ, Leonard H, Ulms B, Grenier-Boley B, Heikkinen S, Garcia-González P, Castillo-Morales A, Kikuchi M, Gim J, Cao H, Küçükali F, Amin N

and 121 more — show all

Yoon D, de Rojas I, Alvarez Jerez P, Alvarez V, Arosio B, Bellenguez C, Bergh S, Billingsley K, Blauwendraat C, Boada M, Borroni B, Bossù P, Bullido MJ, Daniele A, Carracedo Á, de Mendonça A, Cookson M, Deckert J, Dichgans M, Djurovic S, Dols-Icardo O, Dufouil C, Düzel E, Escott-Price V, Fladby T, Fratiglioni L, Fu AKY, Galimberti D, García-Alberca JM, Giedraitis V, Garcia-Ribas G, Graff C, Grimmer T, Grünblatt E, Hanon O, Hausner L, Heilmann-Heimbach S, Hort J, Jessen F, Jensen K, Jonson C, Kim Y, Kuznetsov N, Leinonen V, Lipponen A, Luo J, Makarious M, Martiskainen H, Masullo C, Mecocci P, Mehrabian S, Mir P, Miyashita A, Moebus S, Mok KY, Molina Porcel L, Moreno F, Nacmias B, Parnetti L, Pastor P, Pérez-Tur J, Peters O, Pijnenburg YAL, Piñol-Ripoll G, Popp J, Rainero I, Real LM, Riedel-Heller S, Rodriguez-Rodriguez E, Rongve A, Rossi G, Royo JL, Rujescu D, Saltvedt I, Sáez ME, Sánchez-Valle R, Sanchez-Garcia F, Sandau N, Scarmeas N, Scheffler K, Scherbaum N, Schneider A, Selbæk G, Seripa D, Solfrizzi V, Spallazzi M, Squassina A, Stordal E, Tesi N, Tremolizzo L, Tripathi KP, van der Flier WM, Williams J, Wiltfang J, Aarsland D, Singleton AB, Amouyel P, Debette S, Tsolaki M, Nicolas G, van der Lee S, Holstege H, Fernandez MV, Kehoe PG, Sleegers K, Ingelsson M, Ghidoni R, Andreassen OA, Holmans PA, Sánchez-Juan P, Sims R, Ip NY, Lee KH, Ikeuchi T, Ramirez A, Ruiz A, Hiltunen M, Lambert JC, van Duijn C, Nalls M, Frikke-Schmidt R

Nature genetics · 2026 · PMID 42736378 · open access

Questions about rs77892656

What is rs77892656?

rs77892656 is a single position in the genome, in or near the USP3 gene. Published research associates it with alzheimer's disease in apoe e33 or e44 or e43 genotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs77892656 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs77892656 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs77892656 come from?

GWAS Catalog, Nature genetics 2026, PMID:42736378. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease in APOE e33 or e44 or e43 genotype (rs77892656). MyGeneLog™. https://www.mygenelog.com/variants/rs77892656

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