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Low density lipoprotein cholesterol levels

TNXB · rs7774197

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−24, with 4 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.035 higher (95% confidence interval 0.029-0.041); p = 8 × 10−25.

How common The C allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in an intron of TNXB.

How common each version is

AC
Korean KRGDB
A 93.7% · C 6.3%
Korean Korea4K
A 93.2% · C 6.8%
Japanese ToMMo
A 94.4% · C 5.6%
World gnomAD
A 90.2% · C 9.8%
World 1000 Genomes
A 89.3% · C 10.7%
World TOPMed
A 90.4% · C 9.6%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Low density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Low density lipoprotein cholesterol levels. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Low density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs7774197

What is rs7774197?

rs7774197 is a single position in the genome, in or near the TNXB gene. Published research associates it with low density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7774197 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7774197 come from?

GWAS Catalog, Nature 2021, PMID:34887591. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Low density lipoprotein cholesterol levels (rs7774197). MyGeneLog™. https://www.mygenelog.com/variants/rs7774197

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