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Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 152,447 East Asian ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0224 lower (95% confidence interval 0.014-0.03); p = 4 × 10−8.
How common The G allele had a frequency of about 19% in the people studied.
Where it sits Chromosome 22, band 22q12.1 — in an intron of ZNRF3.
What each result means
A/ANo copy of the version the research linked to Hemoglobin. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Hemoglobin. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Hemoglobin. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs77688610 is a single position in the genome, in or near the ZNRF3 gene. Published research associates it with hemoglobin. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs77688610 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs77688610 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77688610 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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