Thionamide-induced agranulocytosis in Graves' disease
HLA · rs7768644
0 7124Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 21 East Asian ancestry cases with agranulocytosis, 662 East Asian ancestry cases without agranulocytosis; replicated in 21 East Asian ancestry cases with agranulocytosis, 546 East Asian ancestry cases without agranulocytosis.
The effect
The reported allele is A; the catalogue records no effect size
; p = 3 × 10−13.
How common The A allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in an intron of MUC22.
What each result means
A/ATwo copies of the version the research linked to Thionamide-induced agranulocytosis in Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Thionamide-induced agranulocytosis in Graves' disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Thionamide-induced agranulocytosis in Graves' disease. This is the starting point the study compared everyone against.
Nature communications · 2015 · PMID 26151496 · open access
Questions about rs7768644
What is rs7768644?
rs7768644 is a single position in the genome, in or near the HLA gene. Published research associates it with thionamide-induced agranulocytosis in graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7768644 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs7768644 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7768644 come from?
GWAS Catalog, Nature communications 2015, PMID:26151496. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 7124Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Thionamide-induced agranulocytosis in Graves' disease (rs7768644). MyGeneLog™. https://www.mygenelog.com/variants/rs7768644