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Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 384,317 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0198 higher (95% confidence interval 0.014-0.026); p = 6 × 10−10.
How common The G allele had a frequency of about 19% in the people studied.
Where it sits Chromosome 16, band 16p13.3 — in an intron of RBFOX1.
What each result means
A/ANo copy of the version the research linked to Sleep duration. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Sleep duration. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Sleep duration. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs77684884 is a single position in the genome, in or near the RBFOX1 gene. Published research associates it with sleep duration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs77684884 linked to?
On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.
Does having rs77684884 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77684884 come from?
GWAS Catalog, Nature genetics 2019, PMID:30804565. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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