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Body mass index

KCNQ5 · rs77661114

Where this position leads

Conditions: Childhood Body Mass Index, Obesity and Body Weight

rs77661114 Condition: Childhood Body Mass Index Childhood Body Mass Index Condition Condition: Obesity and Body Weight Obesity and Body Weight Condition rs77661114 rs77661114 KCNQ5

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 42,752 African ancestry individuals, 55,525 African American individuals.

The effect Each copy of the G allele shifted the measure 0.0626 higher (95% confidence interval 0.04-0.085); p = 5 × 10−8.

Where it sits Chromosome 6, band 6q13 — in an intron of KCNQ5.

What each result means

A/A No copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Body mass index. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genomics and phenomics of body mass index reveals a complex disease network
Huang J, Huffman JE, Huang Y, Do Valle Í, Assimes TL, Raghavan S, Voight BF, Liu C, Barabási AL, Huang RDL, Hui Q, Nguyen XT
and 26 more — show all
Ho YL, Djousse L, Lynch JA, Vujkovic M, Tcheandjieu C, Tang H, Damrauer SM, Reaven PD, Miller D, Phillips LS, Ng MCY, Graff M, Haiman CA, Loos RJF, North KE, Yengo L, Smith GD, Saleheen D, Gaziano JM, Rader DJ, Tsao PS, Cho K, Chang KM, Wilson PWF, Sun YV, O'Donnell CJ
VA Million Veteran Program
Nature communications · 2022 · PMID 36581621 · open access

Questions about rs77661114

What is rs77661114?

rs77661114 is a single position in the genome, in or near the KCNQ5 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs77661114 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index, Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs77661114 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs77661114 come from?

GWAS Catalog, Nature communications 2022, PMID:36581621. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs77661114). MyGeneLog™. https://www.mygenelog.com/variants/rs77661114

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