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Who was studied 6,536 British ancestry cases, 5,587 Japanese ancestry cases, 388,508 British ancestry controls, 28,870 Japanese ancestry controls.
The effect
Each copy of the G allele carried 1.30 times the odds of Kidney stones (95% confidence interval 1.20-1.42); p = 5 × 10−10.
How common The G allele had a frequency of about 3% in the people studied.
Where it sits Chromosome 6, band 6q25.3 — in an intron of SLC22A2.
What each result means
G/GTwo copies of the version the research linked to Kidney stones. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Kidney stones. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Kidney stones. This is the starting point the study compared everyone against.
Nature communications · 2019 · PMID 31729369 · open access
Questions about rs77648599
What is rs77648599?
rs77648599 is a single position in the genome, in or near the SLC22A2 gene. Published research associates it with kidney stones. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs77648599 linked to?
On MyGeneLog this position is linked to Kidney Stones. The research behind each link, and its sources, are set out on that condition page.
Does having rs77648599 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77648599 come from?
GWAS Catalog, Nature communications 2019, PMID:31729369. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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