VRK2 · rs77622099
Where this position leads
Condition: Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk)
What the study found
Who was studied 53,386 European ancestry cases, 77,258 European ancestry controls, 14,004 East Asian ancestry cases, 16,757 East Asian ancestry controls, 6,152 African American cases, 3,918 African American controls, 1,234 Latino cases, 3,090 Latino controls; replicated in 1,979 European ancestry cases, 142,626 European ancestry controls.
The effect Each copy of the G allele carried 0.92 times the odds of Schizophrenia (95% confidence interval 0.89-0.94); p = 3 × 10−10.
How common The G allele had a frequency of about 93% in the people studied.
Where it sits Chromosome 2, band 2p16.1 — in an intron of VRK2.
rs77622099 is a single position in the genome, in or near the VRK2 gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk). The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature 2022, PMID:35396580. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Schizophrenia (rs77622099). MyGeneLog™. https://www.mygenelog.com/variants/rs77622099