Sensitive

Schizophrenia

VRK2 · rs77622099

Where this position leads

Condition: Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk)

rs77622099 Condition: Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk) Autism Spectrum Disorder and Schizo… Condition rs77622099 rs77622099 VRK2

What the study found

Who was studied 53,386 European ancestry cases, 77,258 European ancestry controls, 14,004 East Asian ancestry cases, 16,757 East Asian ancestry controls, 6,152 African American cases, 3,918 African American controls, 1,234 Latino cases, 3,090 Latino controls; replicated in 1,979 European ancestry cases, 142,626 European ancestry controls.

The effect Each copy of the G allele carried 0.92 times the odds of Schizophrenia (95% confidence interval 0.89-0.94); p = 3 × 10−10.

How common The G allele had a frequency of about 93% in the people studied.

Where it sits Chromosome 2, band 2p16.1 — in an intron of VRK2.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Schizophrenia — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Schizophrenia.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Schizophrenia compared to the general population.
Source

Questions about rs77622099

What is rs77622099?

rs77622099 is a single position in the genome, in or near the VRK2 gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs77622099 linked to?

On MyGeneLog this position is linked to Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk). The research behind each link, and its sources, are set out on that condition page.

Does having rs77622099 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs77622099 come from?

GWAS Catalog, Nature 2022, PMID:35396580. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Schizophrenia (rs77622099). MyGeneLog™. https://www.mygenelog.com/variants/rs77622099

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