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Pediatric steroid sensitive nephrotic syndrome

AHI1 · rs7759971

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 674 European ancestry cases, 6,817 European ancestry controls, 109 African ancestry cases, 7,514 African ancestry controls, 1,311 East Asian ancestry cases, 7,780 East Asian ancestry controls, 193 South Asian ancestry cases, 436 South Asian ancestry controls, 55 Maghrebian ancestry cases, 228 Maghrebian ancestry controls, 98 Other admixed ancestry ancestry cases, 13,248 Other admixed ancestry ancestry controls.

The effect Each copy of the T allele carried 1.34 times the odds of Pediatric steroid sensitive nephrotic syndrome (95% confidence interval 1.24-1.44); p = 1 × 10−13.

Where it sits Chromosome 6, band 6q23.3 — in an intron of AHI1.

What each result means

C/C No copy of the version the research linked to Pediatric steroid sensitive nephrotic syndrome. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Pediatric steroid sensitive nephrotic syndrome. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Pediatric steroid sensitive nephrotic syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome
Barry A, McNulty MT, Jia X, Gupta Y, Debiec H, Luo Y, Nagano C, Horinouchi T, Jung S, Colucci M, Ahram DF, Mitrotti A
and 58 more — show all
Sinha A, Teeninga N, Jin G, Shril S, Caridi G, Bodria M, Lim TY, Westland R, Zanoni F, Marasa M, Turudic D, Giordano M, Gesualdo L, Magistroni R, Pisani I, Fiaccadori E, Reiterova J, Maringhini S, Morello W, Montini G, Weng PL, Scolari F, Saraga M, Tasic V, Santoro D, van Wijk JAE, Milošević D, Kawai Y, Kiryluk K, Pollak MR, Gharavi A, Lin F, Simœs E Silva AC, Loos RJF, Kenny EE, Schreuder MF, Zurowska A, Dossier C, Ariceta G, Drozynska-Duklas M, Hogan J, Jankauskiene A, Hildebrandt F, Prikhodina L, Song K, Bagga A, Cheong H 2nd, Ghiggeri GM, Vachvanichsanong P, Nozu K, Lee D, Vivarelli M, Raychaudhuri S, Tokunaga K, Sanna-Cherchi S, Ronco P, Iijima K, Sampson MG
Nature communications · 2023 · PMID 37120605 · open access

Questions about rs7759971

What is rs7759971?

rs7759971 is a single position in the genome, in or near the AHI1 gene. Published research associates it with pediatric steroid sensitive nephrotic syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7759971 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7759971 come from?

GWAS Catalog, Nature communications 2023, PMID:37120605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Pediatric steroid sensitive nephrotic syndrome (rs7759971). MyGeneLog™. https://www.mygenelog.com/variants/rs7759971

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