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Chronic lymphocytic leukemia

BCL2 · rs77551289

Where this position leads

Condition: Chronic Lymphocytic Leukaemia

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chronic lymphocytic leukemia compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chronic lymphocytic leukemia.

G/G Published research associates this genotype with typical/baseline likelihood of Chronic lymphocytic leukemia — no copies of the reported risk allele.

Source

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Law PJ, Berndt SI, Speedy HE, Camp NJ, Sava GP, Skibola CF, Holroyd A, Joseph V, Sunter NJ, Nieters A, Bea S, Monnereau A

and 85 more — show all

Martin-Garcia D, Goldin LR, Clot G, Teras LR, Quintela I, Birmann BM, Jayne S, Cozen W, Majid A, Smedby KE, Lan Q, Dearden C, Brooks-Wilson AR, Hall AG, Purdue MP, Mainou-Fowler T, Vajdic CM, Jackson GH, Cocco P, Marr H, Zhang Y, Zheng T, Giles GG, Lawrence C, Call TG, Liebow M, Melbye M, Glimelius B, Mansouri L, Glenn M, Curtin K, Diver WR, Link BK, Conde L, Bracci PM, Holly EA, Jackson RD, Tinker LF, Benavente Y, Boffetta P, Brennan P, Maynadie M, McKay J, Albanes D, Weinstein S, Wang Z, Caporaso NE, Morton LM, Severson RK, Riboli E, Vineis P, Vermeulen RC, Southey MC, Milne RL, Clavel J, Topka S, Spinelli JJ, Kraft P, Ennas MG, Summerfield G, Ferri GM, Harris RJ, Miligi L, Pettitt AR, North KE, Allsup DJ, Fraumeni JF, Bailey JR, Offit K, Pratt G, Hjalgrim H, Pepper C, Chanock SJ, Fegan C, Rosenquist R, de Sanjose S, Carracedo A, Dyer MJ, Catovsky D, Campo E, Cerhan JR, Allan JM, Rothman N, Houlston R, Slager S

Nature communications · 2017 · PMID 28165464 · open access

Questions about rs77551289

What is rs77551289?

rs77551289 is a single position in the genome, in or near the BCL2 gene. Published research associates it with chronic lymphocytic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs77551289 linked to?

On MyGeneLog this position is linked to Chronic Lymphocytic Leukaemia. The research behind each link, and its sources, are set out on that condition page.

Does having rs77551289 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs77551289 come from?

GWAS Catalog, Nat Commun 2017, PMID:28165464. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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