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Who was studied 327,435 European ancestry individuals, 5,845 African ancestry individuals, 6,425 South Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.05 lower (95% confidence interval 0.037-0.063); p = 5 × 10−15.
Where it sits Chromosome 11, band 11p15.2 — inside CALCB.
What each result means
C/CNo copy of the version the research linked to Vitamin D levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Vitamin D levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Vitamin D levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs77486197
What is rs77486197?
rs77486197 is a single position in the genome, in or near the CALCB gene. Published research associates it with vitamin d levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs77486197 linked to?
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs77486197 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77486197 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Vitamin D levels (rs77486197). MyGeneLog™. https://www.mygenelog.com/variants/rs77486197