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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 7,280 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.266 lower; p = 3 × 10−13.
Where it sits Chromosome 19, band 19p13.2 — in an intron of CERS4.
What each result means
A/ATwo copies of the version the research linked to Hexosylceramides (FA20:0) (Model 1). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Hexosylceramides (FA20:0) (Model 1). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Hexosylceramides (FA20:0) (Model 1). This is the starting point the study compared everyone against.
Nature communications · 2026 · PMID 42069741 · open access
Questions about rs77436451
What is rs77436451?
rs77436451 is a single position in the genome, in or near the CERS4 gene. Published research associates it with hexosylceramides (fa20:0) (model 1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs77436451 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77436451 come from?
GWAS Catalog, Nature communications 2026, PMID:42069741. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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