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Who was studied 100,671 European ancestry cases, 2,106,212 European ancestry controls.
The effect
Each copy of the A allele carried 0.97 times the odds of Gout (95% confidence interval 0.96-0.98); p = 4 × 10−8.
How common The A allele had a frequency of about 50% in the people studied.
Where it sits Chromosome 6, band 6q14.1 — a synonymous change in PHIP.
What ClinVar records
ClassificationBenign for PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2026-02-03.
ClinVar record 1226668NM_017934.7(PHIP):c.3180T>C (p.Asp1060=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Gout. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Gout. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Gout. This is the starting point the study compared everyone against.
rs7742431 is a single position in the genome, in or near the PHIP gene. Published research associates it with gout. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7742431 linked to?
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs7742431 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7742431 come from?
GWAS Catalog, Nature genetics 2024, PMID:39406924. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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