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Male-pattern baldness

PAX1 · rs77410716

Where this position leads

Condition: Androgenetic Alopecia (Male Pattern Baldness)

rs77410716 Condition: Androgenetic Alopecia (Male Pattern Baldness) Androgenetic Alopecia (Male Pattern… Condition rs77410716 rs77410716 PAX1

What the study found

Who was studied 25,662 British ancestry cases, 17,928 British ancestry controls; replicated in 13,367 European ancestry cases, 11,851 European ancestry controls, 3,436 cases, 2,435 controls.

The effect Each copy of the C allele shifted the measure 0.285 higher (95% confidence interval 0.24-0.32); p = 5 × 10−45.

Where it sits Chromosome 20, band 20p11.22 — between genes, 141.2 kb from LINC01432.

What each result means

C/C Two copies of the version the research linked to Male-pattern baldness. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Male-pattern baldness. That is a smaller link than two copies.
T/T No copy of the version the research linked to Male-pattern baldness. This is the starting point the study compared everyone against.
Source

Questions about rs77410716

What is rs77410716?

rs77410716 is a single position in the genome, in or near the PAX1 gene. Published research associates it with male-pattern baldness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs77410716 linked to?

On MyGeneLog this position is linked to Androgenetic Alopecia (Male Pattern Baldness). The research behind each link, and its sources, are set out on that condition page.

Does having rs77410716 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs77410716 come from?

GWAS Catalog, Nat Commun 2017, PMID:29146897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Male-pattern baldness (rs77410716). MyGeneLog™. https://www.mygenelog.com/variants/rs77410716

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