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Who was studied at least 71,880 European ancestry cases, at least 383,378 European ancestry controls (MTAG boosted by 757,601 blood pressure samples).
The effect
Each copy of the G allele shifted the measure 0.0252 higher (95% confidence interval 0.017-0.033); p = 2 × 10−10.
Where it sits Chromosome 5, band 5q23.2 — between genes, 29.9 kb from KRT18P16.
What each result means
A/ANo copy of the version the research linked to Alzheimer's disease (MTAG). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Alzheimer's disease (MTAG). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Alzheimer's disease (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 39537608 · open access
Questions about rs77399788
What is rs77399788?
rs77399788 is a single position in the genome, in or near the near KRT18P16 gene. Published research associates it with alzheimer's disease (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs77399788 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs77399788 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77399788 come from?
GWAS Catalog, Nature communications 2024, PMID:39537608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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