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Neonatal diabetes mellitus with congenital hypothyroidism

GLIS3 · rs773807925

Where this position leads

Condition: Hypothyroidism

rs773807925 Condition: Hypothyroidism Hypothyroidism Condition rs773807925 rs773807925 GLIS3

Strength of the evidence

There is no record yet to score this position by (a ClinVar disease classification or a genome-wide significant study). That is not the same as weak evidence.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Conflicting classifications of pathogenicity for Inborn genetic diseases, Neonatal diabetes mellitus with congenital hypothyroidism; criteria provided, conflicting classifications (1 of 4 stars, 2 submitters), last evaluated 2025-08-25. ClinVar record 2462615 NM_001042413.2(GLIS3):c.122C>T (p.Ser41Leu)

Classification Likely pathogenic for Neonatal diabetes mellitus with congenital hypothyroidism; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2022-04-06. ClinVar record 2502239 NM_001042413.2(GLIS3):c.122C>A (p.Ser41Ter)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

G/G No copy of the version ClinVar lists as likely disease-causing for Neonatal diabetes mellitus with congenital hypothyroidism. This is the usual result. So far only one lab has made this call, so it may change. (ClinVar VCV002502239, criteria provided, single submitter)
G/T One copy of the version ClinVar lists as likely disease-causing for Neonatal diabetes mellitus with congenital hypothyroidism. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. So far only one lab has made this call, so it may change. (ClinVar VCV002502239, criteria provided, single submitter)
T/T Two copies of the version ClinVar lists as likely disease-causing for Neonatal diabetes mellitus with congenital hypothyroidism. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. So far only one lab has made this call, so it may change. (ClinVar VCV002502239, criteria provided, single submitter)

Source: ClinVar VCV002502239, criteria provided, single submitter

Questions about rs773807925

What is rs773807925?

rs773807925 is a single position in the genome, in or near the GLIS3 gene. Published research associates it with neonatal diabetes mellitus with congenital hypothyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs773807925 linked to?

On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.

Does having rs773807925 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs773807925 come from?

ClinVar VCV002502239, criteria provided, single submitter. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neonatal diabetes mellitus with congenital hypothyroidism (rs773807925). MyGeneLog™. https://www.mygenelog.com/variants/rs773807925

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