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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0212 lower (95% confidence interval 0.015-0.027); p = 3 × 10−13.
How common The A allele had a frequency of about 12% in the people studied.
Where it sits Chromosome 18, band 18q12.3 — between genes, 17.6 kb from LINC01478.
What each result means
A/ATwo copies of the version the research linked to Mean sphered cell volume (UKB data field 30270). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Mean sphered cell volume (UKB data field 30270). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Mean sphered cell volume (UKB data field 30270). This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs77351486
What is rs77351486?
rs77351486 is a single position in the genome, in or near the near LINC01478 gene. Published research associates it with mean sphered cell volume (ukb data field 30270). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs77351486 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs77351486 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77351486 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Mean sphered cell volume (UKB data field 30270) (rs77351486). MyGeneLog™. https://www.mygenelog.com/variants/rs77351486