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Sensitive

Fever in mesalamine-treated irritable bowel disease

OTUD7A · rs77344822

Where this position leads

Conditions: Crohn's Disease, Ulcerative Colitis

rs77344822 Condition: Crohn's Disease Crohn's Disease Condition Condition: Ulcerative Colitis Ulcerative Colitis Condition rs77344822 rs77344822 OTUD7A

What the study found

Who was studied 90 Japanese ancestry cases, 1,433 Japanese ancestry controls; replicated in 22 Japanese ancestry cases, 766 Japanese ancestry controls.

The effect Each copy of the T allele carried 4.78 times the odds of Fever in mesalamine-treated irritable bowel disease (95% confidence interval 4.22-5.34); p = 5 × 10−8.

How common The T allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 15, band 15q13.3 — in an intron of OTUD7A.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Fever in mesalamine-treated irritable bowel disease — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Fever in mesalamine-treated irritable bowel disease.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Fever in mesalamine-treated irritable bowel disease compared to the general population.
Source
Genetic Background of Mesalamine-induced Fever and Diarrhea in Japanese Patients with Inflammatory Bowel Disease
Suzuki K, Kakuta Y, Naito T, Takagawa T, Hanai H, Araki H, Sasaki Y, Sakuraba H, Sasaki M, Hisamatsu T, Motoya S, Matsumoto T
and 32 more — show all
Onodera M, Ishiguro Y, Nakase H, Andoh A, Hiraoka S, Shinozaki M, Fujii T, Katsurada T, Kobayashi T, Fujiya M, Otsuka T, Oshima N, Suzuki Y, Sato Y, Hokari R, Noguchi M, Ohta Y, Matsuura M, Kawai Y, Tokunaga K, Nagasaki M, Kudo H, Minegishi N, Okamoto D, Shimoyama Y, Moroi R, Kuroha M, Shiga H, Li D, McGovern DPB, Kinouchi Y, Masamune A
MENDEL study group
Inflammatory bowel diseases · 2022 · PMID 33501934

Questions about rs77344822

What is rs77344822?

rs77344822 is a single position in the genome, in or near the OTUD7A gene. Published research associates it with fever in mesalamine-treated irritable bowel disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs77344822 linked to?

On MyGeneLog this position is linked to Crohn's Disease, Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs77344822 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs77344822 come from?

GWAS Catalog, Inflamm Bowel Dis 2021, PMID:33501934. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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