Sensitive

Microalbuminuria in type 1 diabetes

MBLAC1 · rs77273076

Where this position leads

What the study found

Who was studied 2,447 European ancestry cases, 12,113 European ancestry controls.

The effect Each copy of the T allele carried 9.16 times the odds of Microalbuminuria in type 1 diabetes; p = 1 × 10⁻⁸.

How common The T allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 7, band 7q22.1 — between genes, 2.4 kb from MBLAC1.

What each result means

C/C No copy of the version the research linked to Microalbuminuria in type 1 diabetes. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Microalbuminuria in type 1 diabetes. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Microalbuminuria in type 1 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen

Salem RM, Todd JN, Sandholm N, Cole JB, Chen WM, Andrews D, Pezzolesi MG, McKeigue PM, Hiraki LT, Qiu C, Nair V, Di Liao C

and 76 more — show all

Cao JJ, Valo E, Onengut-Gumuscu S, Smiles AM, McGurnaghan SJ, Haukka JK, Harjutsalo V, Brennan EP, van Zuydam N, Ahlqvist E, Doyle R, Ahluwalia TS, Lajer M, Hughes MF, Park J, Skupien J, Spiliopoulou A, Liu A, Menon R, Boustany-Kari CM, Kang HM, Nelson RG, Klein R, Klein BE, Lee KE, Gao X, Mauer M, Maestroni S, Caramori ML, de Boer IH, Miller RG, Guo J, Boright AP, Tregouet D, Gyorgy B, Snell-Bergeon JK, Maahs DM, Bull SB, Canty AJ, Palmer CNA, Stechemesser L, Paulweber B, Weitgasser R, Sokolovska J, Rovīte V, Pīrāgs V, Prakapiene E, Radzeviciene L, Verkauskiene R, Panduru NM, Groop LC, McCarthy MI, Gu HF, Möllsten A, Falhammar H, Brismar K, Martin F, Rossing P, Costacou T, Zerbini G, Marre M, Hadjadj S, McKnight AJ, Forsblom C, McKay G, Godson C, Maxwell AP, Kretzler M, Susztak K, Colhoun HM, Krolewski A, Paterson AD, Groop PH, Rich SS, Hirschhorn JN, Florez JC

SUMMIT Consortium, DCCT/EDIC Research Group, GENIE Consortium

Journal of the American Society of Nephrology : JASN · 2019 · PMID 31537649

Questions about rs77273076

What is rs77273076?

rs77273076 is a single position in the genome, in or near the MBLAC1 gene. Published research associates it with microalbuminuria in type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs77273076 linked to?

On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs77273076 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs77273076 come from?

GWAS Catalog, J Am Soc Nephrol 2019, PMID:31537649. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Microalbuminuria in type 1 diabetes (rs77273076). MyGeneLog™. https://www.mygenelog.com/variants/rs77273076

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