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Who was studied 19,865 European ancestry cases, 623,043 European ancestry controls.
The effect
Each copy of the A allele carried 1.10 times the odds of Multiple sclerosis (95% confidence interval 1.08-1.13); p = 3 × 10−12.
How common The A allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 11, band 11q13.4 — in an intron of ARAP1.
What each result means
A/ATwo copies of the version the research linked to Multiple sclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Multiple sclerosis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Multiple sclerosis. This is the starting point the study compared everyone against.
rs77267834 is a single position in the genome, in or near the ARAP1 gene. Published research associates it with multiple sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs77267834 linked to?
On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs77267834 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77267834 come from?
GWAS Catalog, Nature genetics 2026, PMID:42706309. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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