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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 21,758 European ancestry individuals; replicated in 9,173 individuals.
The effect
Each copy of the A allele shifted the measure 0.168 lower; p = 6 × 10−12.
How common The A allele had a frequency of about 4% in the people studied.
Where it sits Chromosome 8, band 8q24.12 — in an intron of SAMD12-AS1.
What each result means
A/ATwo copies of the version the research linked to Osteoprotegerin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Osteoprotegerin levels. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Osteoprotegerin levels. This is the starting point the study compared everyone against.
rs77255899 is a single position in the genome, in or near the SAMD12-AS1 gene. Published research associates it with osteoprotegerin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs77255899 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77255899 come from?
GWAS Catalog, Nature metabolism 2020, PMID:33067605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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