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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 342,339 European ancestry individuals, 6,015 African ancestry individuals, 7,336 South Asian ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0634 higher (95% confidence interval 0.045-0.082); p = 2 × 10−11.
Where it sits Chromosome 12, band 12q24.31 — in an intron of SPPL3.
What each result means
A/ANo copy of the version the research linked to Gamma glutamyl transferase levels. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Gamma glutamyl transferase levels. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Gamma glutamyl transferase levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs77205232
What is rs77205232?
rs77205232 is a single position in the genome, in or near the SPPL3 gene. Published research associates it with gamma glutamyl transferase levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs77205232 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77205232 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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