Sensitive

Neutrophil level response to clozapine in treatment-resistant schizophrenia

ZNF618 · rs77198048

Where this position leads

Condition: Schizophrenia

rs77198048 Condition: Schizophrenia Schizophrenia Condition rs77198048 rs77198048 ZNF618

What the study found

Who was studied 552 Sub-Saharan African ancestry individuals.

The effect Each copy of the T allele shifted the measure 1.62 higher (95% confidence interval 1.07-2.18); p = 9 × 10−9.

How common The T allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 9, band 9q32 — in an intron of ZNF618.

What each result means

A/A No copy of the version the research linked to Neutrophil level response to clozapine in treatment-resistant schizophrenia. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Neutrophil level response to clozapine in treatment-resistant schizophrenia. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Neutrophil level response to clozapine in treatment-resistant schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs77198048

What is rs77198048?

rs77198048 is a single position in the genome, in or near the ZNF618 gene. Published research associates it with neutrophil level response to clozapine in treatment-resistant schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs77198048 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs77198048 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs77198048 come from?

GWAS Catalog, Mol Psychiatry 2019, PMID:30647433. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Neutrophil level response to clozapine in treatment-resistant schizophrenia (rs77198048). MyGeneLog™. https://www.mygenelog.com/variants/rs77198048

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