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Body mass index

MFAP3 · rs7715256

Where this position leads

Condition: Childhood Body Mass Index

rs7715256 Condition: Childhood Body Mass Index Childhood Body Mass Index Condition rs7715256 rs7715256 MFAP3

What the study found

Who was studied 1,122,049 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0168 higher (95% confidence interval 0.014-0.02); p = 1 × 10−30.

Where it sits Chromosome 5, band 5q33.2 — inside MFAP3.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.
T/T Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.
Source
Genomics and phenomics of body mass index reveals a complex disease network
Huang J, Huffman JE, Huang Y, Do Valle Í, Assimes TL, Raghavan S, Voight BF, Liu C, Barabási AL, Huang RDL, Hui Q, Nguyen XT
and 26 more — show all
Ho YL, Djousse L, Lynch JA, Vujkovic M, Tcheandjieu C, Tang H, Damrauer SM, Reaven PD, Miller D, Phillips LS, Ng MCY, Graff M, Haiman CA, Loos RJF, North KE, Yengo L, Smith GD, Saleheen D, Gaziano JM, Rader DJ, Tsao PS, Cho K, Chang KM, Wilson PWF, Sun YV, O'Donnell CJ
VA Million Veteran Program
Nature communications · 2022 · PMID 36581621 · open access

Questions about rs7715256

What is rs7715256?

rs7715256 is a single position in the genome, in or near the MFAP3 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7715256 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.

Does having rs7715256 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7715256 come from?

GWAS Catalog, Nature communications 2022, PMID:36581621. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs7715256). MyGeneLog™. https://www.mygenelog.com/variants/rs7715256

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