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Pediatric autoimmune diseases

ADCY7 · rs77150043

Where this position leads

Condition: Ulcerative Colitis

rs77150043 Condition: Ulcerative Colitis Ulcerative Colitis Condition rs77150043 rs77150043 ADCY7

What the study found

Who was studied 97 European ancestry thyroiditis cases, 107 European ancestry ankylosing spondylitis cases, 100 European ancestry psoriasis cases, 173 European ancestry celiac disease cases, 254 European ancestry systemic lupus erythematosus cases, 308 European ancestry common variable inmunodeficiency cases, 865 European ancestry ulcerative colitis cases, 1,086 European ancestry Type 1 diabetes cases, 1,123 European ancestry juvenile idiopathic arthritis cases, 1,922 European ancestry Crohn's disease cases, 10,718 European ancestry controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 6 × 10−9.

How common The T allele had a frequency of about 23% in the people studied.

Where it sits Chromosome 16, band 16q12.1 — in an intron of ADCY7.

What each result means

C/C No copy of the version the research linked to Pediatric autoimmune diseases. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Pediatric autoimmune diseases. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Pediatric autoimmune diseases. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
Li YR, Li J, Zhao SD, Bradfield JP, Mentch FD, Maggadottir SM, Hou C, Abrams DJ, Chang D, Gao F, Guo Y, Wei Z
and 54 more — show all
Connolly JJ, Cardinale CJ, Bakay M, Glessner JT, Li D, Kao C, Thomas KA, Qiu H, Chiavacci RM, Kim CE, Wang F, Snyder J, Richie MD, Flatø B, Førre Ø, Denson LA, Thompson SD, Becker ML, Guthery SL, Latiano A, Perez E, Resnick E, Russell RK, Wilson DC, Silverberg MS, Annese V, Lie BA, Punaro M, Dubinsky MC, Monos DS, Strisciuglio C, Staiano A, Miele E, Kugathasan S, Ellis JA, Munro JE, Sullivan KE, Wise CA, Chapel H, Cunningham-Rundles C, Grant SF, Orange JS, Sleiman PM, Behrens EM, Griffiths AM, Satsangi J, Finkel TH, Keinan A, Prak ET, Polychronakos C, Baldassano RN, Li H, Keating BJ, Hakonarson H
Nature medicine · 2015 · PMID 26301688

Questions about rs77150043

What is rs77150043?

rs77150043 is a single position in the genome, in or near the ADCY7 gene. Published research associates it with pediatric autoimmune diseases. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs77150043 linked to?

On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs77150043 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs77150043 come from?

GWAS Catalog, Nat Med 2015, PMID:26301688. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pediatric autoimmune diseases (rs77150043). MyGeneLog™. https://www.mygenelog.com/variants/rs77150043

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