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Revision surgery due to aseptic loosening after total joint arthroplasty

ELAPOR2 · rs77149046

What the study found

Who was studied 75 cases from twins, 1,036 controls from twins.

The effect Each copy of the C allele carried 5.40 times the odds of Revision surgery due to aseptic loosening after total joint arthroplasty (95% confidence interval 3.23-9.02); p = 1 × 10−10.

How common The C allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 7, band 7q21.12 — in an intron of ELAPOR2.

What each result means

C/C Two copies of the version the research linked to Revision surgery due to aseptic loosening after total joint arthroplasty. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Revision surgery due to aseptic loosening after total joint arthroplasty. That is a smaller link than two copies.
T/T No copy of the version the research linked to Revision surgery due to aseptic loosening after total joint arthroplasty. This is the starting point the study compared everyone against.
Source

Questions about rs77149046

What is rs77149046?

rs77149046 is a single position in the genome, in or near the ELAPOR2 gene. Published research associates it with revision surgery due to aseptic loosening after total joint arthroplasty. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs77149046 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs77149046 come from?

GWAS Catalog, The Journal of bone and joint surgery. American volume 2022, PMID:34982741. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Revision surgery due to aseptic loosening after total joint arthroplasty (rs77149046). MyGeneLog™. https://www.mygenelog.com/variants/rs77149046

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