Sensitive

Skin cancer

JDP2 · rs77100309

Where this position leads

Condition: Sun Sensitivity, Freckling and Skin Cancer Risk

rs77100309 Condition: Sun Sensitivity, Freckling and Skin Cancer Risk Sun Sensitivity, Freckling and Skin… Condition rs77100309 rs77100309 JDP2

What the study found

Who was studied 25,928 European ancestry cases, 466,275 European ancestry controls, 154 East Asian ancestry cases, 178,572 East Asian ancestry controls.

The effect Each copy of the A allele shifted the measure 0.103 higher (95% confidence interval 0.067-0.139); p = 3 × 10−8.

Where it sits Chromosome 14, band 14q24.3 — in an intron of JDP2.

What each result means

A/A Two copies of the version the research linked to Skin cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Skin cancer. That is a smaller link than two copies.
G/G No copy of the version the research linked to Skin cancer. This is the starting point the study compared everyone against.
Source

Questions about rs77100309

What is rs77100309?

rs77100309 is a single position in the genome, in or near the JDP2 gene. Published research associates it with skin cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs77100309 linked to?

On MyGeneLog this position is linked to Sun Sensitivity, Freckling and Skin Cancer Risk. The research behind each link, and its sources, are set out on that condition page.

Does having rs77100309 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs77100309 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Skin cancer (rs77100309). MyGeneLog™. https://www.mygenelog.com/variants/rs77100309

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