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Psoriasis

IL12B · rs7709212

Where this position leads

Condition: Psoriasis

rs7709212 Condition: Psoriasis Psoriasis Condition rs7709212 rs7709212 IL12B

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Psoriasis — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Psoriasis.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Psoriasis compared to the general population.
Source
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility
Yin X, Low HQ, Wang L, Li Y, Ellinghaus E, Han J, Estivill X, Sun L, Zuo X, Shen C, Zhu C, Zhang A
and 27 more — show all
Sanchez F, Padyukov L, Catanese JJ, Krueger GG, Duffin KC, Mucha S, Weichenthal M, Weidinger S, Lieb W, Foo JN, Li Y, Sim K, Liany H, Irwan I, Teo Y, Theng CT, Gupta R, Bowcock A, De Jager PL, Qureshi AA, de Bakker PI, Seielstad M, Liao W, Ståhle M, Franke A, Zhang X, Liu J
Nature communications · 2015 · PMID 25903422 · open access

Questions about rs7709212

What is rs7709212?

rs7709212 is a single position in the genome, in or near the IL12B gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7709212 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs7709212 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7709212 come from?

GWAS Catalog, Nat Commun 2015, PMID:25903422. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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